Editorial-Details (JLPM)

Mohammad Ibtehaz Alam

Professor
Universidad Nacional de San Luis (UNSL)
Argentina

Biography

Dr. Dario C Ramirez PhD is a Principal Investigator at CONICET and a Professor at the Universidad Nacional de San Luis UNSL Argentina with over 25 years of research experience His work centers on the molecular mechanisms of oxidative stress redox signaling and chronic inflammation in metabolic and endocrine disorders Specifically his research focuses on immunometabolism and adipose tissue remodeling systemic complications driven by neutrophil retention free radical biochemistry involving myeloperoxidase MPO and metabolic risk biomarkers Dr Ramirezs career is marked by productive research on oxidative stress and macrophage mediated inflammation at sites of tissue irritation triggered by metabolic and environmental stressors He has contributed to improving methods for detecting and preventing oxidative damage to macromolecules and has discovered that the nitrone spin trap DMPO can be used as both a discovery tool and a therapeutic to reduce inflammation He strongly believes that hypoxic inflammation may influence tumor biology and the inflammation of obese fat tissue Interestingly both monocyte infiltration and the M1 M2 switch of macrophages can be regulated by hypoxic inflammation within these microenvironments Data from his combined efforts to understand the role of macrophage biology in hypoxic and metabolically stressed microenvironments will elucidate mechanisms and identify targets to prevent inflammation in obese fat tissue and tumor invasiveness or resistance Additionally his projects investigate the mechanism linking lung inflammation in obesity to insulin resistance focusing on neutrophils and myeloperoxidase MPO driven oxidations His teams in vitro and in vivo studies on Western diet induced obesity aim to test whether natural and synthetic products can inhibit MPO reduce NF kB activation and activate Nrf 2 Nrf 2 and PPAR delta agonists may prove effective in promoting adipogenesis reducing macrophage polarization toward an inflammatory phenotype and lowering obesity related metabolic risks Current topics in his laboratory include environmental pollution nutrition metabolism noncommunicable diseases and mechanism based therapeutics.

Research Interest

Oxidative stress, redox signaling, chronic inflammation, immunometabolism, obesity, adipose tissue remodeling, macrophage polarization, neutrophil biology, myeloperoxidase, metabolic disorders, insulin resistance, hypoxic inflammation, tumor biology, environmental pollution, nutrition, metabolism, and mechanism based therapeutics.

ISSN

ISSN No: Under Processing

Journal Information

  • Frequency: Monthly
  • Publication: Online & Print
  • Impact Factor (2024): 0.247
  • Journal Type: Open Access
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