EDITORIAL-DETAILS (JPDM)
Xinming Liu
Assistant Professor
University of Nebraska Medical Center
United States
Biography
Dr. Xinming Liu is an Assistant Professor in the Department of Pharmacology and Experimental Neuroscience, College of Medicine, and a courtesy faculty in the Department of Pharmaceutical Sciences, College of Pharmacy, at the University of Nebraska Medical Center (UNMC). Dr. Liu’s research mainly focuses on the development and evaluation of drug delivery systems, nanomedicine and small molecule prodrugs for the treatment of human diseases. His research is highly technology- and science-driven, with strong translational emphasis on targeted therapy of HIV/AIDS, inflammatory diseases and orofacial diseases. Dr. Liu developed targeted nano-formulated antiretroviral therapeutics (nanoART) that provide efficient HIV inhibition lasting more than 2 weeks after a single dose administration. This set of nanotechnologies has been licensed to a pharmaceutical company, NanoART LLC, which was founded in collaboration with ViiV Healthcare with the goal to develop the first long-acting nanoformulation product for HIV treatment. Other nanotechnologies that Dr. Liu developed include biomineral-binding micelles and liposomes, which were also licensed, and another pharmaceutical company Oravation LLC was founded and is currently developing several nanoformulated anti-plaque mouthwash and toothpaste products. Dr. Liu also developed polymer therapeutics based on HPMA copolymers and multifunctional PEG that provide 3-week anti-inflammatory effects with a single dose. These therapeutics have been licensed by the UNMC Technology Transfer organization (UNeMed Corp.) for the treatment of inflammatory diseases.
Research Interest
Chemically engineering novel biomaterials, drug delivery systems (DDS), nanomedicine, and low-molecular-weight prodrugs for the targeting theranostic application of HIV, CNS diseases, cancer, inflammatory diseases, and orofacial diseases