Journal of Cancer Research and Therapeutic Oncology (JCRTO)
|Subject:||Cancer Research, Molecular Biology, Oncogenes, Oncotherapy, Radiotherapy & Biotherapy, Cancer Nanotechnology|
Journal of Cancer Research and Therapeutic Oncology (JCRTO) is an international open access, scholarly peer-reviewed journal publishing high quality articles in all areas of cancer related fields, especially current research, new concepts, novel methods, new therapeutic agents, and approaches for early detection and prevention of cancer and reporting new methods on basic and advanced clinical aspects of cancer research and therapy.
Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas
The rat parvovirus H-1PV has oncolytic and tumour-suppressive properties potentially exploitable in cancer therapy. This possibility is being explored and results are encouraging, but it is necessary to improve the oncotoxicity of the virus. Here we show that this can be achieved by co-treating cancercells with H-1PV and histone deacetylase inhibitors (HDACIs) such as valproic acid (VPA)
Clinical and experimental data indicate that hyaluronan accumulates in breast cancer compared to normal breast epithelium, which correlates to poor prognosis. In this review we discuss the expression of genes encoding enzymes that synthesize or degrade hyaluronan, i.e. HASes and HYALs, or bind hyaluronan
One hundred and twenty-eight patients with breast cancer who, on the basis of mammographic study, were treated by mastectomy were analyzed. The purpose of this endeavor was to correlate the roentgenologic features with the pathologic findings
Examination of localized NPC tumors by the PCR genotyping assay revealed EBV was present on the tumor side of the nasopharynx in greater quantities than the \"normal\" side in seven of eight patients studied. Concurrent infection with both the prototype F and f variant was observed in two of the eight patients investigated.
David J. Riese II